Status:
RECRUITING
Metastasis-directed Therapy for Oligorecurrent Prostate Cancer
Lead Sponsor:
Universitaire Ziekenhuizen KU Leuven
Conditions:
Prostate Cancer
Prostate Cancer Recurrent
Eligibility:
MALE
18+ years
Phase:
PHASE3
Brief Summary
The aim is to investigate whether the addition of short-term androgen deprivation therapy (ADT) during 1 month or short-term ADT during 6 months together with an androgen receptor targeted therapy (AR...
Detailed Description
Metastasis-directed therapy (MDT) has broadened the therapeutic window in patients presenting with oligorecurrent prostate cancer as it postpones the initiation of palliative androgen deprivation ther...
Eligibility Criteria
Inclusion
- Histologically proven initial diagnosis of prostate adenocarcinoma
- Priory treated and controlled primary tumor
- Biochemical recurrence defined by prostate-specific antigen (PSA) values \>0,2 ng/ml (i.e., two consecutive increases) following radical prostatectomy + postoperative radiotherapy and a PSA value of 2 ng/ml above the nadir after high-dose RT.
- Oligorecurrent disease defined as a maximum of 5 extracranial metastases in any organ, diagnosed on PSMA PET-CT or PSMA PET-MRI reported according to the E-PSMA consensus guidelines for interpretation of PSMA-PET (26). Nodal (N1) disease can be included only when accompanied by M1a-c disease, provided that the total number of spots does not exceed 5.
- Serum testosterone level within normal range.
- WHO performance 0-2
- Age \>= 18 years old
- Absence of psychological, sociological or geographical condition potentially hampering compliance with study protocol.
- Patients must be presented at the multidisciplinary board meeting and the inclusion in the trial needs approval by this board.
- Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures
- 2\. Use of highly effective methods of birth control; defined as those that, alone or in combination, result in low failure rate (i.e., less than 1% per year) when used consistently and correctly; such as implants, injectables, combined oral contraceptives, some IUDs, true sexual abstinence (i.e. refraining from heterosexual intercourse during the entire period of risk associated with the Trial treatment(s)) or commitment to a vasectomised partner.
Exclusion
- Any disorder, which in the Investigator's opinion might jeopardise the participant's safety or compliance with the protocol
- Any prior or concomitant treatment(s) that might jeopardise the participant's safety or that would compromise the integrity of the Trial
- Participation in an interventional Trial with an investigational medicinal product (IMP) or device
- Serum testosterone level at castration level.
- PSA rise while on active treatment (LHRH-agonist, LHRH antagonist, anti-androgen, maximal androgen blockade, oestrogen)
- Presence of poly-metastatic disease, defined as more than 5 metastatic lesions.
- Active malignancy other than prostate cancer that could potentially interfere with the interpretation of this trial.
- Previous treatments (RT, surgery) or comorbidities rendering new treatment with SBRT impossible.
- Contra indications for intake of enzalutamide (seizure or any condition that may predispose to seizure; significant cardiovascular disease within the last three months including myocardial infarction, unstable angina, congestive heart failure, ongoing arrythmias of grade \> 2 or a thromboembolic event).
- Not able to understand the treatment protocol or sign informed consent.
Key Trial Info
Start Date :
April 20 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 25 2032
Estimated Enrollment :
873 Patients enrolled
Trial Details
Trial ID
NCT05352178
Start Date
April 20 2022
End Date
April 25 2032
Last Update
July 3 2024
Active Locations (1)
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1
University Hospitals Leuven
Leuven, Belgium