Status:
RECRUITING
HYDROcortisone Versus Placebo for Severe HospItal-acquired Pneumonia in Intensive Care Patients: the HYDRO-SHIP Study
Lead Sponsor:
Instituto de Assistencia Medica ao Servidor Publico Estadual, Sao Paulo
Collaborating Sponsors:
Instituto do Cancer do Estado de São Paulo
Hospital de Câncer de Barretos
Conditions:
Healthcare-Associated Pneumonia
Ventilator Associated Pneumonia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The use of corticosteroids in patients with severe community pneumonia, bacterial infection which kills lots of patients around the world, reduces the mortality of this infection. However, there are n...
Detailed Description
Introduction and Objectives: the use of corticosteroids in patients with severe community pneumonia reduces morbimortality. However, to our knowledge, there are no studies with steroids for patients i...
Eligibility Criteria
Inclusion
- 18 years of age or older
- Suspected ou confirmed case of bacterial nosocomial pneumonia (including ventilator-associated pneumonia)
- Intensive Care Unit stay
- Signed consent form (by the patient or a legal guardian)
Exclusion
- Women who are pregnant, have recently given birth or are breastfeeding
- Patients who are moribund or do not have a treatment perspective
- Patients with community acquired pneumonia
- Patients with other types of pneumonia (viral - including COVID-19, fungal etc.)
- Those with pulmonary infiltrates in chest image which are not compatible with bacterial pneumonia
- Patients with adrenal insufficiency
- Patients who have a condition that demands the use of corticosteroids (acute or chronic)
- Patients allergic to hydrocortisone
- Patients with refractory septic shock (those receiving more than 0,5mcg/kg/min of norepinephrine)
Key Trial Info
Start Date :
October 16 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2027
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT05354778
Start Date
October 16 2022
End Date
February 1 2027
Last Update
November 25 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Hospital do Servidor Publico Estadual
São Paulo, Sao Paulo SP, Brazil, 04039-901