Status:
COMPLETED
Genetic Determinants of the Coronary Microvascular Obstruction in PCI
Lead Sponsor:
Privolzhsky Research Medical University
Conditions:
Myocardial Infarction
No-Reflow Phenomenon
Eligibility:
All Genders
18+ years
Brief Summary
Myocardial infarction (MI) remains one of the most common causes of death. Percutaneous coronary intervention (PCI) is the main treatment option to restore blood flow through the infarction-related co...
Detailed Description
The aim of the study to identify the genetic determinants of the coronary microvascular obstruction development during percutaneous coronary interventions in myocardial infarction patients. The study ...
Eligibility Criteria
Inclusion
- informed consent to participate in the study;
- male or female 18 years of age or older;
- type 1 ST-segment elevation MI (according to the criteria of the fourth universal definition of myocardial infarction and current clinical guidelines);
- blood sampling in the operating room (immediately after PCI) and signing the informed consent;
- for the "CMVO+" group: CMVO because of PCI (CMVO is registered according to the criteria from the European Society of Cardiology clinical guidelines);
- for the "CMVO-" group: absence of CMVO after PCI; patient should compliance by sex and age (±5 years) with pair in the "CMVO+" group.
Exclusion
- late admission (more than 48 hours from the onset of anginal pain) or early post-infarction angina pectoris;
- not 1 type MI;
- complications during PCI (dissection, perforation or acute intraoperative thrombosis of the IRA);
- death during PCI, not due to the CMVO development;
- concomitant terminal pathology (not associated with MI) with a life expectancy less than 1 month.
Key Trial Info
Start Date :
April 11 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 25 2023
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT05355532
Start Date
April 11 2022
End Date
March 25 2023
Last Update
September 25 2025
Active Locations (2)
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1
City Clinical Hospital No. 13 of the Avtozavodsky District of Nizhny Novgorod
Nizhny Novgorod, Nizhny Novgorod Oblast, Russia, 603018
2
Central Research Laboratory of the Privolzhsky Research Medical University
Nizhny Novgorod, Nizhny Novgorod Oblast, Russia, 603104