Status:
COMPLETED
Remote Ischemic Conditioning, Bimanual Skill Learning, and Corticospinal Excitability
Lead Sponsor:
East Carolina University
Conditions:
Unilateral Cerebral Palsy
Hemiplegic Cerebral Palsy
Eligibility:
All Genders
6-16 years
Phase:
NA
Brief Summary
Unilateral cerebral palsy (UCP) is a leading cause of childhood disability. An early brain injury impairs the upper extremity function, bimanual coordination, and impacts the child's independence. The...
Detailed Description
Ischemic conditioning (IC) is a phenomenon of protecting the target organ from ischemia by directly exposing it to brief episodes of sublethal ischemia. RIC is a clinically feasible way of performing ...
Eligibility Criteria
Inclusion
- Children diagnosed with unilateral cerebral palsy, ages 6-16 years
- Manual Ability Classification System (MACS) levels I-III
- Ability to complete a stack of 3 cups in 2 minutes
- Mainstream in school and has sufficient cognition to follow the experiment instructions
Exclusion
- Children with other developmental disabilities such as autism, developmental coordination disorders, etc.
- Children with absent active motor threshold
- Children with cognitive deficits or communication problem
- Children with known cardiorespiratory and vascular dysfunctions
- Children with metabolic disorders, neoplasm, hydrocephalus
- Children who are receiving other adjunct therapies such as rTMS and tDCS
- Children with seizures and on anti-seizure medications
- Children with metal implants and incompatible medical devices for MRI scans
Key Trial Info
Start Date :
December 18 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 30 2025
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT05355883
Start Date
December 18 2021
End Date
May 30 2025
Last Update
July 16 2025
Active Locations (1)
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1
Dept. of Physical Therapy, East Carolina University
Greenville, North Carolina, United States, 27834