Status:
RECRUITING
GI Oxalate Absorption
Lead Sponsor:
University of Chicago
Collaborating Sponsors:
University of Alabama at Birmingham
Conditions:
Bariatric Surgery Candidate
Kidney Stone
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This study aims to learn more about how oxalate, a compound found in many foods, may affect a person's chances of forming kidney stones. Active participation in this study will last for around one wee...
Detailed Description
The study will be carried out in the University of Chicago Medicine (UCM) Clinical Research Center (CRC). Study Population and Recruitment Enroll 10 post-Roux-en-Y Gastric Bypass stone forming, 10 ob...
Eligibility Criteria
Inclusion
- Post-Roux-en-Y gastric bypass stone formers:
- Age 18-70
- Previous history of Roux-en-Y gastric bypass
- History of at least one calcium-based kidney stone after surgery
- Pre-protocol urine oxalate above the lab normal range (50mg/day)
- Obese stone formers:
- Age 18-70
- Body mass index (BMI) \>=30kg/m2
- History of at least one calcium-based kidney stone
- Pre-protocol urine oxalate above the lab normal range (50mg/day)
- Non-obese stone formers:
- Age 18-70, BMI between 18.5-29.9 kg/m2
- History of at least one calcium-based kidney stone
Exclusion
- Post-Roux-en-Y gastric bypass stone formers:
- History of colon resection (partial or complete)
- History of duodenal switch bowel surgery
- History of ileal-jejunal bypass surgery
- History of primarily uric acid, cysteine, or struvite stones
- Obese and non-obese stone formers:
- History of bowel surgery
- History of colon resection
- History of inflammatory bowel disease (Crohn's disease, Ulcerative Colitis)
- History of primarily uric acid, cysteine, or struvite stones
Key Trial Info
Start Date :
January 25 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 2 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05356000
Start Date
January 25 2023
End Date
August 2 2026
Last Update
August 19 2025
Active Locations (1)
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1
University of Chicago Medical Center
Chicago, Illinois, United States, 60637