Status:
UNKNOWN
The Use of Endoscopic Ultrasound-Guided Portal Pressure Measurements to Guide Beta-Blocker Therapy in Patients With Compensated Cirrhosis
Lead Sponsor:
University of Southern California
Conditions:
Cirrhosis
Compensated Cirrhosis
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
This pilot study to determine the feasibility of EUS-Portal Pressure Measurements to guide Beta-Blocker Therapy in patients with compensated cirrhosis .The study will be a prospective tandem controlle...
Detailed Description
The study will be a prospective tandem controlled trial consisting of 30 patients who are undergoing EGD followed by EUS-PPG at Los Angeles County + University of Southern California Medical Center (L...
Eligibility Criteria
Inclusion
- 18-75 years of age.
- diagnosis of Child-Pugh class A cirrhosis who present to LAC+USC for variceal screening.
- A diagnosis of cirrhosis will be determined histologically based on biopsy alone or clinically by reviewing notes from a gastroenterology or hepatology provider with imaging and clinical history consistent with cirrhosis.
Exclusion
- Prior decompensation, which includes a history of variceal hemorrhage, ascites, and/or hepatic encephalopathy;
- other complications of cirrhosis that can affect portal pressures, such as splenic or portal vein thrombosis and/or hepatocellular carcinoma,
- use of any medications (i.e. current beta-blocker use) or prior procedure that affects splanchnic hemodynamics or portal pressure;
- contraindications to beta-blockers, including resting heart rate \<60, systolic blood pressure \<90, history of bronchospasm;
- current incarceration;
- pregnancy; and
- inability to give informed consent.
Key Trial Info
Start Date :
December 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05357599
Start Date
December 1 2023
End Date
July 1 2025
Last Update
March 6 2023
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