Status:
UNKNOWN
Physical Training for People With Parkinson's Disease and Multiple Sclerosis: Effect on Mind and Body
Lead Sponsor:
Amsterdam UMC, location VUmc
Collaborating Sponsors:
Netherlands Brain Foundation
Conditions:
Parkinson Disease
Multiple Sclerosis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
People with Parkinson's disease and Multiple Sclerosis experience disabling motor and non-motor symptoms, which respond insufficiently to medication. To adequately alleviate disease burden, physical t...
Detailed Description
Next to complex motor deficits, people with Parkinson's disease and Multiple Sclerosis experience highly disabling non-motor symptoms; for example, anxiety and depression, cognitive decline, fatigue, ...
Eligibility Criteria
Inclusion
- Diagnosis of Parkinson's Disease (PD) or Progressive Multiple Sclerosis (MS)
- Hoehn \& Yahr stage \<4 (PD), Expanded Disability Status Scale score \<6 (MS)
- Anxiety and/or depressive symptoms; Hospital Anxiety and Depression Scale (HADS) score \>=8 points on HADS-A and/or HADS-D
- Sufficient cognitive ability to understand training instructions; Montreal Cognitive Assessment score \>21 points
- Able to participate in intensive physical training, no contra-indications for exercise
- Stable medication regime for at least 4 weeks prior to inclusion
- Age \>=18 years
Exclusion
- Participation in intensive exercise program in the month prior to inclusion
- Relapse in the month prior to inclusion (MS)
- Symptoms indicating cardiovascular, pulmonary, or metabolic disease or cardiovascular, pulmonary, or metabolic disease which are not under control with medication
- abnormal electrocardiography in rest
Key Trial Info
Start Date :
May 2 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 2 2025
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT05357638
Start Date
May 2 2022
End Date
November 2 2025
Last Update
April 25 2023
Active Locations (1)
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1
Amsterdam UMC, location VU medical center
Amsterdam, North Holland, Netherlands, 1081HZ