Status:
WITHDRAWN
Improvement of the Operative Outcome in Patients With Primary VEGF + Unifocal Breast Cancer or DCIS Through the Intraoperative Visualization of the Tumor Using Molecular Imaging and Bevacizumab-IRDye-800CW
Lead Sponsor:
Technical University of Munich
Conditions:
Breast Cancer
Eligibility:
MALE
18+ years
Phase:
PHASE2
Brief Summary
It is a prospective, open, non-randomized, multicenter, one-armed, blinded (surgeon), diagnostic clinical trial according to AMG and MPG. The fluorescent marker Bevacizumab-IRDye800CW has advantages o...
Detailed Description
Complete surgical excision of the tumor (R0 resection) is the cornerstone of any curative therapy concept for cancer. In order to be able to achieve the highest possible rate of R0 resections, the tum...
Eligibility Criteria
Inclusion
- women of age ≥ 18 years able to give consent who have been informed in detail about the study beforehand and have given written consent to participate
- Patients with histologically confirmed unifocal VEGF-positive invasive breast cancer with an indication for BET
- Patients with histologically confirmed unilateral VEGF-positive DCIS with an indication for BET
- ECOG performance ≤ 2
- Pre-menopausal women had a negative pregnancy test prior to administration of the study medication
- Negative pregnancy test (serum) within 10 days prior to administration of the test medication in all women of childbearing age with results available prior to the start of therapy (or postmenopausal; age ≥60 and no menses over ≥ 1 year without any other medical cause; or hysterectomy, or tube ligation, or bilaterally guided occlusion). Women of childbearing potential who are sexually active must agree that they and their partner may use effective contraception during the trial and for 3 months after participation
Exclusion
- Second malignancy in the breast and other organs
- Pregnant or breastfeeding patients
- Planned sentinel lymph node marking using patent blue
- Previous radiation therapy in the area to be examined
- Known or suspected hypersensitivity to the study medication (according to IMPD / SmPC) or other immunoglobulins
- Currently after neoadjuvant (primarily systemic) chemotherapy and anti-hormone therapy
- Immunotherapy (e.g. monoclonal antibodies, cytokines or signal transduction inhibitors) in the last 28 days prior to the declaration of consent
- Previous therapy with bevacizumab
- Planned reconstruction in the breast to be examined
- Previous surgery within the last 28 days prior to the declaration of consent
- Non-healing wounds, ulcers or broken bones within the last 28 days prior to giving informed consent
- Patients with ileus within the last 28 days prior to the declaration of consent
- Non-adjustable hypertension (\> 145/90 mmHg) despite optimal drug therapy
- Insufficient kidney function (serum creatinine\> 1.5 x upper limit of the normal range)
- Current or recent treatment with another investigational drug in another clinical trial within 28 days of informed consent
- Potentially fertile women without adequate contraception. Safe contraceptive measures are procedures with a Pearl index of ≤ 1%
- Patients with other serious illnesses that pose an unreasonable risk for participating in the study
- Persons who are in a dependent / employment relationship with the sponsor or investigator
- Persons who are to be or are to be accommodated in an institution due to a court or official order
Key Trial Info
Start Date :
June 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2023
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT05359874
Start Date
June 1 2021
End Date
March 1 2023
Last Update
May 4 2022
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