Status:
COMPLETED
Prone Positioning and R/I Ratio in COVID-19 Patients With ARDS (SyDRAC-DV)
Lead Sponsor:
Centre Hospitalier Universitaire de Nice
Conditions:
COVID-19 Acute Respiratory Distress Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to determine the efects of prone positioning on the recruitment- to-inflation ratio in COVID-19 patients with acute respiratory distress syndrome.
Detailed Description
High positive end-expiratory pressure (PEEP) level and prone positioning (PP) are recommended in patients with moderate to severe acute respiratory distress syndrome (ARDS) in order to recruit lung an...
Eligibility Criteria
Inclusion
- Invasive mechanical ventilation
- Patients with acute respiratory distress syndrome according to the Berlin definition
- Positive COVID-19 real-time reverse transcriptase-polymerase chain reaction assay in nasal swabs or pulmonary samples.
- Indication to a prone positioning session by the attending physician
Exclusion
- Age \<18 years and pregnant women
- Patients under legal protection
- Acute core pulmonale
- Pneumothorax and/or chest drainage
- Hemodynamic failure
- Increase in norepinephrine dosage \>30% within the last 6 hours
- Norepinephrine dosage \> 0.5 mg/kg/min
Key Trial Info
Start Date :
November 3 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 29 2023
Estimated Enrollment :
92 Patients enrolled
Trial Details
Trial ID
NCT05360862
Start Date
November 3 2022
End Date
September 29 2023
Last Update
February 8 2024
Active Locations (1)
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1
CHU de NICE
Nice, France, 06200