Status:
COMPLETED
PAS for Post-SCI Neuropathic Pain
Lead Sponsor:
Helsinki University Central Hospital
Conditions:
Spinal Cord Injury Cervical
Neuropathic Pain
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The investigators have shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output i...
Eligibility Criteria
Inclusion
- incomplete cervical spinal cord injury
- time from injury at least 1.5 years
- chronic SCI- induced neuropathic pain in the upper limb
Exclusion
- Diagnosed brain damage, visible in MRI or CT.
- No activity in hands/fingers and no MEPs recorded from distal hand muscles.
- Epilepsy
- Metal inclusion in the head area
- High intracranial pressure
- Pacemaker
- Implanted hearing device
- Progressive diseases of spinal cord or brain (e.g. malignant tumors, degenerative diseases).
- Previous head or spinal cord injury affecting the motor performance of upper extremities.
- Congenital anomaly in the anatomical structure of spinal canal/cord or dura.
- Significant systemic disease or other condition that could cause neurological deficit, or may affect subject's capability to undergo investigation-related procedures.
- Acute severe infection.
- Contraindications for MRI.
- Current severe psychiatric diseases.
- Current chronic drug and/or alcohol abuse.
- Pregnancy.
- Pressure ulcer affecting the subject's capability to undergo the procedure safely
Key Trial Info
Start Date :
April 22 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 22 2023
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT05362422
Start Date
April 22 2022
End Date
September 22 2023
Last Update
September 25 2023
Active Locations (1)
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1
Helsinki University Hospital
Helsinki, Finland