Status:
COMPLETED
Novel Urine-Based DNA Methylation Biomarkers for Urothelial Bladder Carcinoma Detection in Patients With Hematuria
Lead Sponsor:
Mansoura University
Conditions:
Bladder Cancer
Eligibility:
18+ years
Phase:
NA
Brief Summary
The current study aimed to assess the diagnostic performance of novel urine-based DNA hypermethylation of six genes (GATA4, P16, P14, APC, CDH1 and CD99) for UBC detection in patients with hematuria.
Detailed Description
According to GLOBOCAN data, bladder cancer (BC) is considered a major health problem that represents 3% of all cancer diagnoses. Urothelial bladder carcinoma (UBC) accounts for the vast majority (\>90...
Eligibility Criteria
Inclusion
- patients with hematuria (macroscopic or microscopic)
Exclusion
- history of Bladder Cancer
- history of pelvic irradiation,
- bleeding diathesis or receiving anticoagulants
- patients with upper urinary tract neoplasm or urolithiasis
Key Trial Info
Start Date :
February 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2022
Estimated Enrollment :
246 Patients enrolled
Trial Details
Trial ID
NCT05362539
Start Date
February 1 2019
End Date
April 1 2022
Last Update
May 5 2022
Active Locations (1)
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1
Mansoura Urology and Nephrology Center
Al Mansurah, DK, Egypt, 35516