Status:
UNKNOWN
The Cerebral-Respiratory Interaction in Controlled Mechanically Ventilated Neurosurgical Patients. (The CeRes-CMV Study)
Lead Sponsor:
Uppsala University
Conditions:
Mechanical Ventilation Complication
Neurological Disorder
Eligibility:
All Genders
18+ years
Brief Summary
The impact of mechanical ventilation on intracranial perfusion is still not completely clarified. It is often assumed that raising airway pressure will invariably elevate the intracranial pressure, bu...
Eligibility Criteria
Inclusion
- The patients will be included within 48 hours from initiation of mechanical ventilation and insertion of an external ventricular drainage catheter
- Age \>18 years;
- MV expected for more than 72 hours;
- Not pregnant;
- Informed consent from patient or next of kin.
Exclusion
- Previously demonstrated paralysis of the diaphragm or know pathology of the phrenic nerve or neuromuscular disorder,
- Chest tube,
- Patients with clinical conditions that contraindicate the insertion of esophageal/gastric catheters (e.g., esophagus rupture, esophageal bleeding),
- Pacemaker and/or implantable cardioverter defibrillator, these last being a contraindication for EIT.
- Hemicraniectomy. In case of late hemicraniectomy (after patient inclusion), the patient will drop-out from the study.
- Relative contraindication: in case of skull base fracture the patient can be included only if oesophageal/gastric and NAVA catheters can be inserted orally.
Key Trial Info
Start Date :
May 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2023
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05363085
Start Date
May 1 2022
End Date
May 1 2023
Last Update
May 5 2022
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