Status:
COMPLETED
Investigation of the Effects of Dietary Fibres on the Gut Microbiome in a Transgenerational Cohort
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
Biotechnology and Biological Sciences Research Council
Société des Produits Nestlé (SPN)
Conditions:
Gut Health
Eligibility:
FEMALE
18-85 years
Phase:
NA
Brief Summary
Dietary fibres are complex carbohydrates present in fruit, vegetables, grains, and beans which are broken down into smaller molecules (short-chain fatty acids) in the colon by the gut microbiota. Incr...
Detailed Description
Eligible participants will need to take daily for 14 days a dietary fibre supplement or placebo (depending on the randomisation) followed by wash-out period of 14 days and then followed by taking dail...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Any of the following groups of people (in direct descent and from the same family) Grandmother, mother and daughter Mother and daughter Grandmother and granddaughter
- Age 18-85 (inclusive)
- BMI: 18.5-30 kg/m2 (inclusive)
- Considering themselves healthy
- Exclusion Criteria
- Intake of antibiotics in the past 3 months and during the study
- Intake of probiotic supplements in the past month and during the study
- Regular intake of laxatives in the past month and during the study
- Subjects with the following conditions Inflammatory Bowel Disease (IBD) Irritable Bowel Syndrome (IBS) Coeliac Disease Type 2 Diabetes Any type of cancer Autoimmune conditions Conditions that affect the liver Conditions that affect the pancreas
- Subjects who require medical intervention in the coming 3 months
- Smokers
- Shift workers
- Gluten and/or lactose intolerance
- Pregnant and lactating women
- Subjects living in care homes
- had weight changes \>5% in the preceding 3 months
- Subjects who are unable to give informed consent by themselves
- Subjects who are currently participating in other clinical trials
Exclusion
Key Trial Info
Start Date :
October 4 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 4 2023
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT05364437
Start Date
October 4 2022
End Date
April 4 2023
Last Update
April 29 2025
Active Locations (1)
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1
NIHR Imperial Clinical Research Facility
London, United Kingdom, W12 0HS