Status:
UNKNOWN
Hemodynamic Effects of Two Modalities of Alveolar Recruitment Maneuvers - ICU Patients
Lead Sponsor:
University Hospital, Clermont-Ferrand
Conditions:
Cardiac Output
Hemodynamic Optimization
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The objective of this study was to investigate the hemodynamic effects of two alveolar recruitment maneuver strategies in critical care patients with acute respiratory distress syndrome.
Detailed Description
Critical care patients are at risk of significant variations in blood volume due to long intervention times, major bleeding or serious pathological conditions, requiring invasive hemodynamic monitorin...
Eligibility Criteria
Inclusion
- Patient over 18 years old
- Patient under general anesthesia
- Intubated patient under controlled invasive mechanical ventilation
- Patient with invasive hemodynamic monitoring allowing monitoring of cardiac output and stroke volume
- Patient sufficiently sedated (BIS between 40 and 60) and/or curarized (TOF \< 2/4 at the orbicularis) to avoid inspiratory effort
- Patient optimized on the hemodynamic level, in particular with regard to blood volume, following the data from hemodynamic monitoring and the recommendations of the French Society of Anesthesia and Resuscitation (RFE SFAR 2013 - Perioperative Vascular Filling Strategy)
- Patient covered by a Social Security plan
- Consent of close relatives or trusted person (if present)
- Patient admitted in polyvalent resuscitation within the Peri-Operative Medicine Unit of Clermont-Ferrand hospital suffering from respiratory distress syndrome for less than 24 hours
Exclusion
- Contraindication to the use of cardiac output measurement by transpulmonary thermodilution
- Cardiac arrhythmia
- Severe valvulopathy
- Contraindication to the use of the Analysis of pulmonary aeration will be performed using the non-invasive technique of electrical impedance tomography with the placement of an electrode belt on the patient's chest. Values will be recorded with this belt :
- technique
- Left ventricular ejection fraction (LVEF) \< 45% and/or right ventricular failure
- History of pulmonary lobectomy and/or pneumectomy and/or known emphysema
- Patient with restrictive or obstructive lung disease
- Body mass index (BMI) \< 16.5 or \> 30 kg.m-2
- Pregnancy
- Major under legal protection (guardianship, curators, safeguard of justice)
Key Trial Info
Start Date :
March 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2024
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05365854
Start Date
March 1 2022
End Date
March 1 2024
Last Update
May 12 2022
Active Locations (1)
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1
CHU
Clermont-Ferrand, France, 63000