Status:
COMPLETED
Effect of Intrapulmonary Percussion Ventilation on Deposition of Inhaled Aerosols in Idiopathic Pulmonary Fibrosis
Lead Sponsor:
University Hospital, Tours
Collaborating Sponsors:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Idiopathic Pulmonary Fibrosis
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
This protocol aims to evaluate the feasibility and benefit of Intrapulmonary Percussive Ventilation (IPV) to improve deposition of inhaled radiolabelled aerosols in fibrotic lung regions of patients w...
Eligibility Criteria
Inclusion
- Diagnosis of IPF according to 2018 ATS/ERS/JRS/ALAT guidelines
- Affiliation to health insurance
- Signed informed consent
Exclusion
- Other chronic lung disease
- Airflow obstruction (FEV1/FVC\<0.7)
- History of congestive heart failure
- History of IPF exacerbation
- History of lung cancer
- Chronic cough precluding aerosol delivery and radioprotection
- Claustrophobia
- 24h/24 oxygen therapy
- Any acute lung disease
- Any potentially transmissible lung infection
- Current or possible pregnancy and breastfeeding
- Contra-indications to IPV : Emphysema, recent barotrauma, pneumothorax, pneumomediastinum
- History of pneumothorax or pneumomediastinum
- Patient unable to hold a mouthpiece tightly
- Patient under legal protection (guardianship, curatorship)
- Contraindication to the administration of Technescan DTPA
Key Trial Info
Start Date :
November 23 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 12 2025
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT05366387
Start Date
November 23 2022
End Date
February 12 2025
Last Update
December 1 2025
Active Locations (1)
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1
Pulmonology Department, University Hospital, Tours
Tours, France, 37044