Status:
NOT_YET_RECRUITING
Minocycline Efficacy in Improving Neurological Outcome of Patients Who Undergo Endovascular Revascularization for Acute Ischemic Stroke
Lead Sponsor:
State University of New York at Buffalo
Conditions:
Acute Ischemic Stroke
Eligibility:
All Genders
18-100 years
Phase:
PHASE2
Brief Summary
The study will be a prospective, randomized, double- blinded placebo, single center pilot clinical trial. Patients with acute ischemic stroke due to large vessel occlusion undergoing endovascular thro...
Detailed Description
Overall Design and Rationale for the Study Design The study will be a prospective, randomized, double- blinded placebo, single center pilot clinical trial. Patients with acute ischemic stroke due to l...
Eligibility Criteria
Inclusion
- provision of consent, either by self or authorized representative, willingness and ability to participate in study procedures
- Acute onset focal neurologic deficit consistent with acute ischemic stroke, or computed tomographic scan consistent with acute cerebral ischemia
- Age more than 18 years
- Premorbid Rankin score ≤ 3
- Treatment with intra-arterial endovascular revascularization methods.
- Patients should be given first dose of minocycline as soon as possible, latest by 24 hours after the endovascular stroke intervention
Exclusion
- Allergy/ Intolerance to tetracycline antibiotics
- Pregnant women - positive pregnancy test on admission or known to be pregnant
- ALT or AST \> 3 times the upper limit of normal
- Serum creatinine \> 2 mg/dL
- Patient is participating in another clinical trial at any time during the duration of the study that could confound the treatment or outcomes of this investigation; and/or
- Has a severe health condition that may potentially result in death within 6 months.
Key Trial Info
Start Date :
December 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2027
Estimated Enrollment :
134 Patients enrolled
Trial Details
Trial ID
NCT05367362
Start Date
December 1 2025
End Date
June 1 2027
Last Update
May 18 2025
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