Status:
COMPLETED
Is Labetalol More Effective Than Metoprolol for Controlled Hypotensive Anesthesia During Endoscopic Nasal Surgeries?
Lead Sponsor:
Damanhour Teaching Hospital
Conditions:
Hypotension Drug-Induced
Eligibility:
All Genders
21-50 years
Phase:
PHASE4
Brief Summary
Background: Mucosal bleeding is the most frequent complication with endoscopic nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, leading to increased complica...
Eligibility Criteria
Inclusion
- American Society of Anesthesiologists (ASA) physical status ≤ II
- Age from 21 to 50 years
- Body Mass Index (BMI) ≤ 35 kg/m2
Exclusion
- ASA physical status \> II
- Age \< 21 years or \> 50 years
- Pregnant women
- Breastfeeding
- Bronchial asthma
- Chronic obstructive pulmonary disease
- Hypertension
- Ischemic heart disease
- Rheumatic heart disease
- Heart failure
- Heart block
- Sick sinus syndrome
- Sinus bradycardia
- Chronic hypotension
- Anemia (Hb \< 10 g/dl)
- Renal or hepatic dysfunction
- Central nervous system disease
- Bleeding diathesis
- Diabetes Mellitus
- Allergic fungal sinusitis
- Patients on beta-blockers, tricyclic antidepressants, alcohol or drug abuse, anticoagulation therapy, agents influencing the autonomic nervous system
- Patients using pacemakers
- Allergy to the study drugs
- Any contraindication of oral intake
Key Trial Info
Start Date :
April 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 15 2022
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05368376
Start Date
April 1 2021
End Date
October 15 2022
Last Update
September 28 2023
Active Locations (1)
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1
Damanhour Teaching Hospital
Damanhūr, El-Beheira, Egypt