Status:
UNKNOWN
Peri-operative Inflammaging in the Elderly After Surgery
Lead Sponsor:
University of Bonn
Conditions:
Aging
Immunology
Eligibility:
All Genders
80+ years
Brief Summary
The population older than 80 years will significantly increase in the near future. Older patients' cognitive and physical status is known to deteriorate after surgery, leading to a high 30-day mortali...
Eligibility Criteria
Inclusion
- age ≥ 80 years
- elective major surgery defined as knee / hip replacement, spondylodesis (\> 2 levels), gastrectomy, resection of esophagus, liver, pancreas, colon, rectum or lung
Exclusion
- no informed consent
- not able to perform neurocognitive testing
- preexisting infection systemic: CRP\>100 mg/l, Leukos \>12.0 G/l or clinical signs
- Prosthetic joint infection (MSIS 2011 criteria):
- PJI is present when 1 major criteria exist or 4 out of 6 minor criteria exist
- Major criteria:
- 2 positive periprosthetic cultures with phenotypically identical organisms
- A sinus tract communicating with the joint
- Minor criteria:
- Elevated CRP and ESR
- Elevated synovial fluid WBC count or ++ change on leukocyte esterase test strip
- Elevated synovial fluid PMN%
- Presence of purulence in the affected joint
- Positive histologic analysis of periprosthetic tissue
- A single positive culture
- Immunosuppression (HIV, glucocorticoids, immunosupressants)
- Autoimmune diseases
- ongoing or recent (\<3 months) chemo/radiotherapy
Key Trial Info
Start Date :
December 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 30 2025
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT05368896
Start Date
December 1 2022
End Date
March 30 2025
Last Update
February 28 2023
Active Locations (1)
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1
University Hospital Bonn
Bonn, Germany, 53127