Status:
RECRUITING
Mini Bolus for Fluid Challenge Responsiveness in the Emergency Department
Lead Sponsor:
University of Monastir
Conditions:
Fluid Therapy
Eligibility:
All Genders
18-80 years
Phase:
EARLY_PHASE1
Brief Summary
Intravascular volume expansion is a common intervention in critically ill patients with acute circulatory failure.we test the hypothesis that a mini-bolus fluid challenge, of either 50 ml , can predic...
Detailed Description
Background: Intravascular volume expansion is a common intervention in critically ill patients with acute circulatory failure. Nevertheless, approximately 50% of critically ill patients will not bene...
Eligibility Criteria
Inclusion
- Patients with spontaneous breathing
- Patients in whom a fluid challenge is indicated because they present acute circulatory failure (which is defined as systolic blood pressure less than 90 mmHg or the need for vasopressors (norepinephrine more than 0.1 µg/kg/min) to maintain a systolic blood pressure more than 90 mmHg (14), and at least one sign of inadequate tissue perfusion:
- urine output of below 0.5ml/kg per hour over 1 hour
- tachycardia (heart rate of greater than 100 beats per minute)
- mottled skin.
- lactate \> 2 mmol/l
Exclusion
- Cardiac arrest
- Acute respiratory distress syndrome
- Coma Glasgow Scale \< 14
- Age of less than 18 years
- Moribund patients
- Pregnant patients
- impossibility to perform passive leg raising (PLR) (trauma patients, lower extremity amputees, and prone patients)
- Patients with cardiac arrhythmias
- Patients with cardiogenic pulmonary oedema
Key Trial Info
Start Date :
March 3 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 22 2025
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT05369559
Start Date
March 3 2022
End Date
May 22 2025
Last Update
July 9 2024
Active Locations (2)
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1
Emergency Departement
Monastir, Tunisia, 5000
2
Emergency department
Monastir, Tunisia