Status:
RECRUITING
Causal Role of Brain Networks in Episodic Memory
Lead Sponsor:
Boston College
Conditions:
Episodic Memory
Healthy
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
The goal of this study is to understand the basic brain mechanisms supporting episodic memory in healthy young adults. Transcranial magnetic stimulation will be used to influence brain activity in reg...
Detailed Description
In this study, healthy young adult participants will complete three sessions: an MRI session for collecting structural and functional brain images and two sessions including transcranial magnetic stim...
Eligibility Criteria
Inclusion
- Ages 18 to 35 years old
- Fluent in English
- Free of major neurological or psychiatric illness
- Right-handed
- Normal or corrected to normal vision
Exclusion
- History of a psychiatric illness within the past two years
- History of a learning disorder (e.g., attention deficit disorder, dyslexia)
- History of neurological disorder or brain injury, including family history of epilepsy, convulsions or seizures, stroke; vascular, traumatic, tumoral, infectious, or metabolic lesion of the brain, even without a history of seizure, and without anticonvulsant medication, and any unexplained lifetime loss of consciousness/syncope
- Use of medications that reduce seizure threshold (e.g., tricyclic antidepressants, neuroleptic agents)
- History of neurosurgery
- History of heart disease
- Recreational drug use in the past two months
- Uncontrollable shaking, or inability to sit/lie still for one hour
- Evidence of neurological disorders or structural abnormalities, based on MRI
- Pregnancy
- Prior surgeries, conditions, and/or implants that are not MRI-safe, including: pacemaker, pacemaker wires, artificial heart valve, brain aneurysm surgery, middle ear implant, non-removable hearing aids, braces, or extensive dental work, implanted mechanical or electrical device, artificial limb or joint
- Foreign metallic objects in the body, such as bullets, BBs, shrapnel, or metalwork fragments
- History of metal work or ocular metallic foreign bodies
- History of uncontrolled migraines or susceptibility to headaches
- Use of centrally-acting medications and drugs, with the exception of caffeine, within the last 12 hours
- Concurrent treatment with ototoxic medications
- Current sleep deprivation, extreme fatigue, or recent jet lag
- Claustrophobia
- Pre-existing noise induced hearing loss
- Any prior adverse experience (e.g. physical or psychological discomfort) with repetitive TMS or MRI scanning
Key Trial Info
Start Date :
October 6 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05374551
Start Date
October 6 2023
End Date
December 31 2025
Last Update
April 16 2025
Active Locations (1)
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1
Boston College
Chestnut Hill, Massachusetts, United States, 02467