Status:
COMPLETED
To Evaluate if Dexmedetomidine Infusion Provides Renal Protection in Patients Undergoing Coronary Artery Bypass Graft
Lead Sponsor:
National Institute of Cardiovascular Diseases, Pakistan
Conditions:
Acute Kidney Injury
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
PHASE3
Brief Summary
OBJECTIVE: Aim of this study is to follow and compare the changes in serum creatinine and urine output up to 48 hours of surgery in patients receiving dexmedetomidine infusion in addition to standard ...
Detailed Description
INTRODUCTION: The incidence of cardiac surgery-associated acute kidney injury (CSA-AKI) varies from 5 to 42%.1 This percentage was found to be 7.86% according to study conducted in Pakistan. 2 Severe...
Eligibility Criteria
Inclusion
- Ages ranged between 18 and 65 years.
- Patients undergoing isolated coronary artery bypass grafting.
- Class II and III ASA physical status.
Exclusion
- Patients with preoperative renal impairment (elevated creatinine and blood urea nitrogen levels) and diuretic use.
- Preexisting hepatic or pulmonary disease, peripheral vascular disease, previous cardiac surgery, emergency surgery, reopening surgeries, surgeries requiring a deep hypothermic circulatory arrest.
- Preoperative use of inotropes or vasopressors.
- Perioperative use of diuretics.
- Perioperative episode of CPR.
- Diabetic patients.
- Preoperative hemoglobin level less than 12 mg/dl.
- Hematological disorders.
- Morbidly obese patients.
Key Trial Info
Start Date :
August 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 31 2022
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05375188
Start Date
August 1 2021
End Date
January 31 2022
Last Update
May 16 2022
Active Locations (1)
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1
NICVD Karachi
Karachi, Sindh, Pakistan, 75100