Status:
RECRUITING
Splanchnic Venous Capacitance in Postural Tachycardia Syndrome
Lead Sponsor:
Vanderbilt University Medical Center
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Postural Tachycardia Syndrome (POTS)
Eligibility:
All Genders
18-50 years
Phase:
PHASE2
Brief Summary
Postural tachycardia syndrome (POTS) affects ≈3 million young people, characterized by chronic presyncopal symptoms characterized by dizziness, lightheadedness, and orthostatic tachycardia that occur ...
Detailed Description
The Aim 1 of the study is to investigate that the worsening orthostatic tachycardia and symptoms after glucose ingestion in POTS patients are due to a greater increase in splanchnic venous capacitance...
Eligibility Criteria
Inclusion
- Between 18 and 50years of age
- Cases: Diagnosis of POTS with presyncope symptoms after meals Or
- Controls:
- With no significant past medical history, non-smokers and not on chronic medications.
- Body mass index (BMI) between 18.5 to 29.9 kg/m2
- If pre-menopausal women: must have regular menstrual cycle.
Exclusion
- BMI above ≥30 kg/m2
- Irregular menstrual cycle
- Intolerance to CPAP.
- Chronic use of acetaminophen
- Heart problems: myocardial infarction, angina, heart failure, stroke
- Undergone any heart related procedures or stents or on pacemaker.
- Uncontrolled hypertension.
- Type 1 or type 2 diabetes mellitus
- Pregnant or breast-feeding women.
- Impaired liver function
- Impaired Kidney function test.
- Anemia (Hematocrit\<34%).
- Ongoing substance abuse.
- Subjects with abnormal EKG
- History of seizures.
- Diagnosed with neuropathy due to any reason
- History of neck surgery.
- Smoker,
- On statin therapy for high cholesterol
- Rheumatoid arthritis.
- On oral corticosteroids,
- Current infections
- Documented of moderate decrease in blood volume
Key Trial Info
Start Date :
February 25 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2028
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05375968
Start Date
February 25 2023
End Date
June 1 2028
Last Update
December 5 2025
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232