Status:
UNKNOWN
AI for Anti-hypertensive Medication Titration
Lead Sponsor:
Alexandra Hospital
Collaborating Sponsors:
National University Hospital, Singapore
Conditions:
Hypertension
Cardiovascular Diseases
Eligibility:
All Genders
30-80 years
Phase:
NA
Brief Summary
Hypertension - a chronic condition of elevated blood pressure (BP) - is a highly prevalent condition. However, effective prevention and management of hypertension remain challenging under the current ...
Detailed Description
The primary aim is to assess the feasibility of CURATE.AI-assisted dose titration intervention (daily home BP monitoring via telemonitoring BotMD Care platform combined with personalized continuous do...
Eligibility Criteria
Inclusion
- At least \>=30 years of age and \<=80 years
- History of uncontrolled primary hypertension, BPs more \>=140/90mm Hg, treatment-naive or on single antihypertensive medication
- Not known to have complications of hypertension
- Sufficiently fluent in English language
- Able to give informed consent
- eGFR \> 60 ml/min
- Eligible to undergo CCB + ARB/ACE-i therapy for =30 days
Exclusion
- Suspected or known secondary hypertension
- Drug allergies to anti-hypertensive agents or agents of the same drug class used in the protocol
- Known postural hypotension or standing systolic blood pressure \< 110 mmHg
- Malignant hypertension (BPs = 180/110 mmHg) that requires emergency treatment
- Arm circumference that does not fit BP cuff size which can affect the accuracy of BP measurement
- Pregnant women, trying to become pregnant or of child-bearing potential and not using birth control
- History of cancer
- Chronic kidney disease (eGFR \<50ml/min) or end stage renal failure
- Liver cirrhosis or hepatic failure
- Chronic heart failure
- Chronic lung disease
- Diabetes Mellitus on insulin and/or with microvascular/macrovascular complications.
- Established cardiovascular disease such as stroke/transient ischemic attack and ischemic heart disease
- Potential psychosocial factors or serious medical conditions limiting the ability to self-monitor their blood pressure or limit adherence to interventions (E.g. dementia, active substance abuse, nursing home resident)
- Participants without informed consent
Key Trial Info
Start Date :
April 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 20 2024
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT05376683
Start Date
April 1 2023
End Date
April 20 2024
Last Update
May 6 2023
Active Locations (1)
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1
Alexandra Hospital
Singapore, Singapore, 159964