Status:
RECRUITING
Neural Mechanisms of Response Inhibition Training for OCRD
Lead Sponsor:
University of Wisconsin, Milwaukee
Conditions:
Obsessive-Compulsive Disorder
Tricholemmoma
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The impaired ability to suppress an inappropriate but pre-potent response (response inhibition; RI) characterizes several debilitating clinical problems, including obsessive-compulsive and related dis...
Detailed Description
Research has documented abnormal inhibition-related brain activity as well as impaired behavioral performance of RI in OCRD. Despite the growing evidence suggesting a RI deficit as a fundamental proce...
Eligibility Criteria
Inclusion
- age between 18 and 60
- moderate level of OCRD symptoms (Yale-Brown Obsessive Compulsive Scale total ≥ 16, Massachusetts General Hospital-Hair pulling Scale total ≥ 12, or Skin Picking Scale-Revised total ≥ 7)
- a primary diagnosis of OCRD (i.e., OCD, TTM, or SPD)
- estimated IQ \> 80
- presence of a RI deficits (SSRT ≥ 215ms).
Exclusion
- Current substance use disorder
- Severe ADHD
- Lifetime diagnosis of psychotic disorder, bipolar disorder, or schizophrenia
- Current psychotherapy
- Change in psychotropic medication status within 8 weeks before the study or during the study
- Use of stimulant medication
- Active suicidal risk
- Contraindications for MRI procedures
Key Trial Info
Start Date :
December 22 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2027
Estimated Enrollment :
118 Patients enrolled
Trial Details
Trial ID
NCT05377125
Start Date
December 22 2022
End Date
August 1 2027
Last Update
July 19 2024
Active Locations (1)
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1
UWM Anxiety Disorders Laboratory
Milwaukee, Wisconsin, United States, 53211