Status:
UNKNOWN
Neuroinflammation and Alzheimer's Pathology in POCD
Lead Sponsor:
University of Tennessee Graduate School of Medicine
Collaborating Sponsors:
Alzheimer's Association
Conditions:
Post-Operative Confusion
Neuroinflammatory Response
Eligibility:
All Genders
60+ years
Brief Summary
The purpose of this project is to investigate the role of both neural inflammation and pre-existing neurodegenerative pathology in the risk and pathogenesis of post-operative cognitive dysfunction (PO...
Detailed Description
The purpose of this project is to investigate the role of both neural inflammation and pre-existing neurodegenerative pathology in the risk and pathogenesis of post-operative cognitive dysfunction (PO...
Eligibility Criteria
Inclusion
- Males and females 60 years or older in age
- Subjects scheduled to undergo TKA
- Fluent and literate in English
- Able to give consent for themselves based upon the MacArthur Competence Assessment Tool for Clinical Research
- Able to have a subarachnoid block with only intravenous sedation
Exclusion
- Less than 60 years of age
- Cognitively impaired to the point where they are unable to give consent for themselves
- Blindness or partial blindness
- Pre-existing neurodegenerative conditions
- Contraindication for subarachnoid block and/or requiring general anesthesia
Key Trial Info
Start Date :
November 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2022
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT05378659
Start Date
November 1 2021
End Date
September 30 2022
Last Update
May 18 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Robert M Craft
Knoxville, Tennessee, United States, 37920