Status:
RECRUITING
Serial Gut Microbiome and Bacterial Gene Markers Changes After Endoscopic Resection of Colorectal Advanced Neoplasia
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Colorectal Cancer
Colorectal Neoplasms
Eligibility:
All Genders
18-90 years
Brief Summary
The investigators hypothesize that gut microbiome composition and the four bacterial gene markers (M3) show dynamic changes after endoscopic resection of advanced neoplasia, some key bacteria are asso...
Detailed Description
Colorectal cancer (CRC) is one of the most common cancers in Hong Kong with more than 5,500 new cases annually. The majority of CRC cases are derived from benign colorectal adenomas through the proces...
Eligibility Criteria
Inclusion
- Subjects require endoscopic resection (e.g. endoscopic mucosal resection or endoscopic submucosal dissection) for advanced adenoma or early-stage colorectal cancer;
- Aged 18-90 years old;
- Written informed consent obtained.
Exclusion
- Absolute contraindications to colonoscopy (e.g. perforation, intestinal obstruction, unstable cardiopulmonary status);
- Contraindications to endoscopic resection (e.g. active gastrointestinal bleeding, uninterrupted anticoagulation or dual antiplatelets);
- Known pregnancy or lactation;
- Advanced comorbid conditions (defined as American Society of Anesthesiologists grade 4 or above);
Key Trial Info
Start Date :
September 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 15 2024
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05381792
Start Date
September 1 2022
End Date
December 15 2024
Last Update
August 27 2024
Active Locations (1)
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1
Prince of Wales Hospital
Shatin, New Territories, Hong Kong