Status:
COMPLETED
Computational Cognitive Training To Boost Reward Responsiveness In Anhedonic Patients
Lead Sponsor:
University of California, San Diego
Conditions:
Anhedonia
Depression
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Anhedonia, i.e., reduced positive mood and decreased sensitivity to rewards, is observed in many psychiatric illnesses, particularly depression and anxiety disorders. Untreated anhedonia predicts wors...
Eligibility Criteria
Inclusion
- Age 18-65 (all races, both males and females will be included)
- Current diagnosis of Major Depressive Disorder (MDD) or Generalized Anxiety Disorder (GAD)
- A score \< 7 on the Snaith-Hamilton Pleasure Scale (SHAPS) or \< 25 on the Positive Affect subscale from the Positive And Negative Affect Scale (PANAS)
- Sufficient proficiency in English language to understand and complete informed consent, interviews, questionnaires, and all other study procedures.
- Having normal or corrected vision
- Having normal or corrected hearing
Exclusion
- Endorsement of past or current psychotic or bipolar disorder.
- Endorsement of recent severe alcohol or substance use disorder (past 3 months).
- Inability to discontinue for 48 hours prior to scan any medications incompatible with measuring reliable/interpretable neural activity (e.g., e.g., benzodiazepines/beta-blockers, atypical anti-depressants, anxiolytics and sedative hypnotics, antipsychotics, and opioid analgesics)
- Being unsafe to undergo functional magnetic resonance imaging (fMRI), i.e., being pregnant, presence of non-removable metal in body, medical conditions that are incompatible with safe MRI (e.g., claustrophobia, inability to lie still on one's back for approximately 60 minutes; prior neurosurgery)
- Clinical conditions assessed by the interviewer that necessitate more imminent clinical care (e.g., active suicidal ideation): These criteria are in place so participants with these other, more several symptoms can be referred for appropriate mental health services.
Key Trial Info
Start Date :
September 14 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 16 2023
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05383248
Start Date
September 14 2022
End Date
November 16 2023
Last Update
November 29 2023
Active Locations (1)
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1
UCSD Center for Functional Magnetic Resonance Imaging
La Jolla, California, United States, 92093