Status:
RECRUITING
Valuation in Depressed Mood, Anhedonia, and Anxiety
Lead Sponsor:
Virginia Polytechnic Institute and State University
Conditions:
Neurobehavioral Components of Reward and Loss Valuation
Eligibility:
All Genders
25-50 years
Phase:
NA
Brief Summary
This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.
Detailed Description
This study tests relationships among neural and behavioral valuation mechanisms, and how these mechanisms change (or not) over time, with task instructions, and following cognitive behavior therapy.
Eligibility Criteria
Inclusion
- mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games.
Exclusion
- history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI
Key Trial Info
Start Date :
August 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2026
Estimated Enrollment :
252 Patients enrolled
Trial Details
Trial ID
NCT05384158
Start Date
August 1 2021
End Date
July 1 2026
Last Update
September 9 2025
Active Locations (1)
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1
Fralin Biomedical Research Institute at Virginia Tech Carilion
Roanoke, Virginia, United States, 24014