Status:
RECRUITING
Feasibility of Cell-Free DNA Liquid Biopsy in Screening High-Risk Patients for Lung Cancer
Lead Sponsor:
City of Hope Medical Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Lung Carcinoma
Eligibility:
All Genders
50-80 years
Phase:
NA
Brief Summary
This clinical trial investigates how practical and doable (feasibility) cell-free deoxyribonucleic acid (DNA) liquid biopsy is in screening high-risk patients for lung cancer. Currently, a low dose co...
Detailed Description
PRIMARY OBJECTIVE: I. To determine the feasibility of lung cancer screening using liquid biopsy in a community setting. SECONDARY OBJECTIVES: I. To determine screening follow-through rates in those...
Eligibility Criteria
Inclusion
- Documented written informed consent of the participant.
- Age 50-80 years.
- Smoking history of \>= 20 pack-years and if quit, quit within 15 years.
- Received referral for counseling for lung cancer screening and would qualify for LDCT.
- Health Insurance that will pay for a LDCT for lung cancer screening at either City of Hope Duarte, Newport Beach (Newport Diagnostic Imaging), or Lancaster (Renaissance Imaging/Antelope Valley Outpatient Imaging Center).
- Willingness to provide blood sample.
- English speaking.
- Consent to undergo lung cancer screening with either liquid biopsy (LB) or LDCT.
Exclusion
- Symptoms of lung cancer.
- Chest CT scan or chest positron emission tomography (PET)/CT within 12 months.
- Any cancer diagnosis within past 5 years, excluding non-melanoma skin cancer.
- Unable to undergo LDCT at either City of Hope Duarte, Newport Beach, or Lancaster.
Key Trial Info
Start Date :
July 29 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 28 2029
Estimated Enrollment :
108 Patients enrolled
Trial Details
Trial ID
NCT05384769
Start Date
July 29 2022
End Date
January 28 2029
Last Update
October 7 2025
Active Locations (1)
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1
City of Hope Medical Center
Duarte, California, United States, 91010