Status:
UNKNOWN
Autologous Platelet-rich Plasma (PRP) Infusion to Improve Outcomes in Women With Ovarian Insufficiency: a Pilot Study
Lead Sponsor:
KK Women's and Children's Hospital
Conditions:
Diminished Ovarian Reserve
Premature Ovarian Insufficiency
Eligibility:
FEMALE
21-40 years
Phase:
NA
Brief Summary
The investigators propose a pilot study to determine if autologous platelet-rich plasma (PRP) improves ovarian reserves and In-vitro fertilisation (IVF) outcomes in women with diminished ovarian reser...
Detailed Description
Ovarian aging is a principal limiting factor for success in both spontaneous and assisted reproductive techniques (ART) conceptions. This results in diminished ovarian reserve (DOR) and premature ovar...
Eligibility Criteria
Inclusion
- Inclusion criteria
- Diminished ovarian reserves AND/OR;
- Anti-Mullerian Hormone (AMH) 0.2-0.5ng/ml or
- At least 2 Follicle Stimulating Hormone (FSH) readings of \>25 (mIU/L) or
- AFC \< 5
- Poor Ovarian Response of \<4 oocytes retrieved at a prior IVF stimulation cycle with gonadotrophin doses of 450u per day
- Exclusion criteria
- Amenorrhea of \> 1 years
- Medical conditions - Diabetes Mellitus, Hypertension, Collagen vascular diseases, Thyroid disease
- Patients presenting with anemia and thrombophilic disorders
- Inability to be monitored for at least 1 year at the treating centre
- Lack of suitable sperm for Intracytoplasmic Sperm Injection (ICSI) (eg. Azoospermia)
Exclusion
Key Trial Info
Start Date :
May 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05385848
Start Date
May 1 2022
End Date
March 1 2024
Last Update
May 23 2022
Active Locations (1)
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1
KK Women's and Children's Hospital
Singapore, Singapore, 229899