Status:
COMPLETED
Concurrent Trigger Sensitivity Adjustment And Diaphragmatic Facilitation On Weaning From Mechanical Ventilation
Lead Sponsor:
Cairo University
Conditions:
Acute Respiratory Failure
Mechanically Ventilated Patients
Eligibility:
All Genders
50-60 years
Phase:
NA
Brief Summary
As Acute respiratory failure (ARF) is a challenging serious condition especially when it necessitates intubation to deliver mechanical ventilation which is a fundamental strategy for supporting the re...
Detailed Description
Physiotherapist is a key member of multidisciplinary team and plays an vital role in ICU in improving the patient's quality of life, Inspiratory muscle training (IMT) applies a load to the diaphragm a...
Eligibility Criteria
Inclusion
- Patients of both sexes with age ranges (50-60) years old.
- Patients will be referred with acute respiratory failure (ARF) inside ICU.
- All patients are intubated and mechanically ventilated with assisted control (pressure or volume) or pressure support modes for 24-48 hours.
- All patients with positive end expiratory pressure (PEEP) don't exceed 10 cmH2o.
- All patients are hemodynamically stable; temperature (36.2-37.5) C, Heart rate \< 140 /min, Blood pressure (systolic: \<180mmHg and diastolic \<100 mmHg), Respiratory rate \< 35/min and oxygen saturation \>90%
- All patients are conscious and responsive to verbal command.
Exclusion
- Fraction of inspired oxygen (fio2)\>0.6 and SPO2 \< 85% to avoid further hypoxia and respiratory distress.
- Positive end expiratory pressure (PEEP) \> 10 cmH2O to avoid barotrauma.
- Severe pulmonary condition; acute pulmonary embolism, undrained pneumothorax.
- Unstable hemodynamic condition as defined by heart rate more than 140 beats/min, systolic blood pressure \>180 mmHg or Low blood pressure \< 80 mmHg and respiratory rate is exceeding 35 breaths/min.
- Patients who develop any cardiac condition during the course of treatment; acute myocardial infarction or cardiac arrhythmia.
- Patients who recently have undergo cardiac or abdominal or gynecological surgery.
- Active lung infection like tuberculosis.
- Chest trauma such as rib fracture, flail chest, thoracic vertebra fracture or chest burns.
- Spinal cord injuries involved the phrenic nerve.
- Active bleeding as alveolar hemorrhage, hemoptysis.
- Heavy sedation that depresses respiratory drive or ability to follow commands.
Key Trial Info
Start Date :
December 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 30 2022
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT05387720
Start Date
December 1 2020
End Date
November 30 2022
Last Update
August 31 2023
Active Locations (1)
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1
Faculty of physical therapy - Cairo University
Giza, Egypt, 12613