Status:
RECRUITING
Metatranscriptomic Next Generation Sequencing in First Trimester Trophoblast With Increased Fetal Nuchal Translucency (METAHCN)
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
Pathogen Discovery Laboratory
Institut Pasteur
Conditions:
Increased Nuchal Translucency in the First Trimester of Pregnancy
Eligibility:
FEMALE
18+ years
Brief Summary
The study is based on the hypothesis that increased nuchal translucency may be associated with a materno fetal infection and that the pathogen responsible for this infection could be identify with met...
Detailed Description
Nuchal translucency \> 3.5 mm in the first trimester of pregnancy is due to fluid accumulation in the subcutaneous tissue in the nuchal area. This is seen in around 1% of all pregnancies. Increased nu...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Pregnant women
- Singleton pregnancy
- First trimester (11 GA+0D to 13 GA+6D)
- Carrying a fetus with a nuchal translucency \> 3.5 mm for which a chorionic villi sampling is performed OR a suspicion of genetic abnormalities for which a chorionic villi sampling is performed
- Delivery planned at Necker hospital
- Not opposed to participation
- Exclusion Criteria
- Age \<18 years
- no health insurance
- difficulties in understanding the French language
- chronic infection (HIV, HBV, HVC and HTLV-1)
Exclusion
Key Trial Info
Start Date :
November 7 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2026
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT05388968
Start Date
November 7 2022
End Date
February 1 2026
Last Update
May 3 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Hopital Necker - Enfants malades
Paris, France, 75015