Status:
RECRUITING
Study on the Optimal Diagnosis and Treatment Strategy of Major Depressive Disorder Based on Anhedonia
Lead Sponsor:
Peking University
Conditions:
Outpatients / Inpatients With Depression
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
This study is a multicenter clinical research and focuses on the exploring of optimal diagnosis and treatment strategies of MDD based on anhedonia.
Detailed Description
Major depressive disorder (MDD) is a heterogeneious psychiatric disorder with complex etiology and pathogenesis. The lack of objective criteria for diagnosis and the use of trial-and-error treatment s...
Eligibility Criteria
Inclusion
- Major depressive disorder according to Diagnostic and Statistical Manual of Mental Disorders (5th edition) (DSM-5);
- Age: 18-55 (including 18 and 55)
- HAMD-17≥18
- DARS ≤ 28
- Do not receive repetitive Transcranial Magnetic Stimulation (rTMS) or modified electroconvulsive therapy (MECT) treatment in past six months.
- Sign the informed consent form voluntarily and agree to participate in all visits, examinations and treatment as required by the trial protocol.
Exclusion
- Patients who are diagnosed with major somatic diseases;
- Patients who meet DSM-5 diagnostic criteria for other mental disorders: Personality disorder, mental retardation; drug and/or alcohol dependence;
- Patients with severe suicidal tendencies or suicidal behavior;
- Pregnant or lactating women;
- Patients with MRI contraindications;
- Patients who are regarded as unsuitable by investigators for this clinical trial.
Key Trial Info
Start Date :
August 15 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
252 Patients enrolled
Trial Details
Trial ID
NCT05389046
Start Date
August 15 2022
End Date
December 1 2025
Last Update
January 17 2024
Active Locations (3)
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1
Beijing Xicheng District Pingan Hosptial
Beijing, Beijing Municipality, China, 100035
2
Beijing Huilongguan Hospital
Beijing, Beijing Municipality, China, 100096
3
Peking University Sixth Hospital
Beijing, Beijing Municipality, China, 100191