Status:
COMPLETED
Neuromodulation Using Vagus Nerve Stimulation Following Ischemic Stroke as Therapeutic Adjunct
Lead Sponsor:
Washington University School of Medicine
Conditions:
Acute Ischemic Stroke
Eligibility:
All Genders
18-99 years
Phase:
NA
Brief Summary
This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory laboratory values and explore clinical outcomes in patients who present with ischemic strokes d...
Detailed Description
Stroke is a leading cause of death and disability worldwide. Approximately 80% of strokes are caused by cerebral ischemia. Although stroke is the third leading cause of death after heart disease and c...
Eligibility Criteria
Inclusion
- Adult patients who present with acute ischemic strokes due to large vessel occlusions
Exclusion
- \<18 years old
- patients with presumed chronic large vessel occlusions
- NIHSS\<6
- pre-morbid modified Rankin score (mRS) \>2
- unable to initiate treatment under 36 hours from symptom discovery
- Chronic or severe infection
- life expectancy \<3 months
- patients' undergoing active cancer or immunosuppressive/modulating therapy
- patients with sustained bradycardia on arrival with a heart rate \<50 beats per minute.
Key Trial Info
Start Date :
September 26 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 23 2024
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05390580
Start Date
September 26 2022
End Date
August 23 2024
Last Update
October 31 2025
Active Locations (1)
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1
Washington University in St. Louis School of Medicine
St Louis, Missouri, United States, 63110