Status:
COMPLETED
Comparison Arterial Blood Pressure and Cardiac Index-based Hemodynamic Management on Postoperative Myocardial Injury
Lead Sponsor:
Istanbul Saglik Bilimleri University
Conditions:
Myocardial Injury
Perioperative/Postoperative Complications
Eligibility:
All Genders
45+ years
Phase:
NA
Brief Summary
The primary aim of this study is to compare mean arterial pressure (MAP) and cardiac index (CI) based intraoperative hemodynamic management in terms of postoperative high sensitive troponin elevation....
Detailed Description
Fluid therapy will be started as 2-4 ml/kg/h, according to the clinician's decision for the patient. Afterwards, patients will be managed hemodynamically with one of the MAP and CI algorithms. Target...
Eligibility Criteria
Inclusion
- Patients who will undergo pancreatic-hepatic surgery
- Patients over 65 years of age or patients over 45 years of age and with at least one of the following comorbidities:
- coronary artery disease, Congestive heart failure, moderate to severe heart valve disease, peripheral artery disease Moderate to Severe Pulmonary hypertension, cerebrovascular accident older than 1 month, History of pulmonary embolism more than 1 month old, Diabetes Mellitus, Hypertension
Exclusion
- Presence of atrial fibrillation, sepsis, pulmonary embolism
- Presence of pulmonary embolism, acute coronary syndrome and cerebrovascular accident in the last month
- Static respiratory system compliance \< 35ml/cmH2O
- Patients with preoperative high sensitive Troponin T value \>65ng/liter
- glomerular filtration rate \< 60 ml/min
- Exclusion criteria during the protocol:
- Newly developed arrhythmia, embolism, sepsis,
- Cancellation of planned surgery
- Postoperative hepatic failure defined as INR\>2
Key Trial Info
Start Date :
June 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2023
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT05391087
Start Date
June 1 2022
End Date
June 30 2023
Last Update
July 5 2023
Active Locations (1)
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1
Başakşehir Çam and Sakura City Hospital
Istanbul, Turkey (Türkiye)