Status:
ACTIVE_NOT_RECRUITING
Tau Pet Imaging in the Aging Brain Cohort Dedicated to Diversity Study
Lead Sponsor:
University of Pennsylvania
Collaborating Sponsors:
Pennsylvania Department of Health
Conditions:
Cognitive Decline
Alzheimer Disease
Eligibility:
All Genders
65+ years
Brief Summary
We will conduct a Tau PET scan in cognitively normal older adults, enrolled in the Aging Brain Cohort Dedicated to Diversity Study (ABCD2-Tau) study at the University of Pennsylvania's Penn Memory Cen...
Eligibility Criteria
Inclusion
- Males and females African Americans ≥ 65 years of age.
- Part of the ABCD2 longitudinal cohort, protocol 844047, of the PMC/ADCC with consensus conference designation of normal cognition.
- ABCD2 longitudinal visit must be completed or scheduled to be completed within 1 year prior to the \[18F\]AV-1451 TAU PET scan.
- A brain MRI must be performed within 1 year prior to their study \[18F\]AV-1451 TAU PET scan date and be deemed of adequate quality that the scan may be used for study analysis, including 3T high-resolution imaging of medial temporal lobe structures.
- An amyloid PET scan completed or scheduled within 1year of their study \[18F\]AV-1451
- Women must be post-menopausal or surgically sterile.
Exclusion
- Have any medical or psychiatric conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, including major depression and prior head trauma.
- Have evidence of structural abnormalities such as major stroke or mass on MRI that is likely to interfere with analysis of the PET scan.
- Inability to tolerate or contraindication to imaging procedures in the opinion of an investigator or treating physician.
- Have a history of significant ongoing alcohol or substance abuse or dependence based on self-report.
- Women of child bearing potential
- The inclusion / exclusion criteria will be ascertained through self-report in conjunction with any medical history available through the participant's medical or research records (EPIC or the ADC database)\*
Key Trial Info
Start Date :
July 6 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2027
Estimated Enrollment :
111 Patients enrolled
Trial Details
Trial ID
NCT05393388
Start Date
July 6 2022
End Date
May 1 2027
Last Update
November 26 2025
Active Locations (1)
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1
Hospital of the University of Pennsylvania - Penn Memory Center
Philadelphia, Pennsylvania, United States, 19104