Status:
RECRUITING
Electroclinical Correlation of Anxiety
Lead Sponsor:
University Hospital, Bordeaux
Collaborating Sponsors:
Centre National de la Recherche Scientifique, France
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Anxiety Disorder
Generalized Anxiety Disorder
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Anxiety disorders have the highest prevalence among mental disorders and cause considerable individual and financial costs. Current treatments do not relieve mental suffering of many patients. Underst...
Detailed Description
Functional imaging work has made it possible to identify the brain regions involved in anxiety disorders but is insufficient to study the pathophysiological mechanisms that cause anxiety symptoms. Bra...
Eligibility Criteria
Inclusion
- Man or woman
- Aged 18 to 65;
- With drug-resistant epilepsy
- Benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG
- Meeting the DSM-5 diagnostic criteria for generalized anxiety disorder ("pathological" population) or not meeting the DSM-5 diagnostic criteria for generalized anxiety disorder ("control" population)
- WAIS IV full scale IQ \> 75 or IAG \> 81
- Affiliate or beneficiary of a social security scheme
- Giving free, informed consent in writing and signed by the participant and the investigator
Exclusion
- Being unable to give personal consent
- Be subject to a measure of legal protection (curatorship, guardianship) or placed under judicial protection;
- Suffer from a chronic delusional disorder (eg: schizophrenia);
- Have a moderate or high risk of suicide assessed using the corresponding section of the structured psychiatric interview called "Mini International Neuropsychiatric Interview" (M.I.N.I. 7.0) or a score \> 2 on item 10 of the MADRS, assessing suicidal risk;
- Being pregnant or breastfeeding
- Have severe and / or decompensated somatic illness other than drug-resistant epilepsy
Key Trial Info
Start Date :
October 11 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 11 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05393518
Start Date
October 11 2022
End Date
October 11 2026
Last Update
July 25 2025
Active Locations (1)
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1
CHU de Bordeaux
Bordeaux, France, 33076