Status:
ACTIVE_NOT_RECRUITING
Blood Vessel Anatomy and Blood Flow Regulation
Lead Sponsor:
University of Wisconsin, Madison
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Brain Blood Flow
Healthy
Eligibility:
All Genders
55-69 years
Brief Summary
Brain blood flow regulation will be measured in response to environmental changes using MRI.
Detailed Description
Global brain blood flow decreases with advancing age; however, some adults have accelerated declines in brain blood flow, placing them at a greater risk of cognitive impairment. Similarly, brain react...
Eligibility Criteria
Inclusion
- BMI ≤38.5 kg/m2
- Nonsmoker
- Female subjects: postmenopausal
- Currently enrolled in the Wisconsin Alzheimer's Disease Research Clinical Core
Exclusion
- Diagnosis of mild cognitive impairment or Alzheimer's disease
- Uncontrolled hypertension
- History or evidence of hepatic disease, hematological disease, or peripheral vascular disease
- Severe kidney injury requiring hemodialysis
- Cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia
- History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease
- History of HIV/AIDS
- Severe untreated obstructive sleep apnea
- History of diabetes with HbA1c greater than 9.5%
- Major neurologic disorders other than dementia (e.g., multiple sclerosis, amyotrophic lateral sclerosis, brain surgery, etc.)
- Current or recent (\<1 year) major psychiatric condition (Axis I) or addictive disorders
- Contraindications to MRI
Key Trial Info
Start Date :
July 19 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2026
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT05396287
Start Date
July 19 2022
End Date
July 1 2026
Last Update
July 18 2025
Active Locations (1)
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1
University of Wisconsin-Madison
Madison, Wisconsin, United States, 53706