Status:
UNKNOWN
Efficacy of Azithromycin Plus Doxycycline Versus Doxycycline Plus Placebo in Patients With Rocky Mountain Spotted Fever
Lead Sponsor:
Hospital General de Mexicali
Conditions:
Rocky Mountain Spotted Fever
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The aim of this study is to impove the pharmacological treatment of Rocky mountain spotted fever, since is a very ancient disease with an antibiotic therapy that have not changed much the mortality ra...
Detailed Description
Rocky mountain spotted fever is a potentially fatal infectious disease wich is transmitted trough vectors. This particular infection is caused by Rickettsia rickettsii wich is a gramnegative intracell...
Eligibility Criteria
Inclusion
- Any gender
- Over 18 years old
- hospitalized in the internal medicine service, emergency department or intensive care unit of Hospital General de Mexicali (ISESALUD) or Hospital General Zona No. 30 (IMSS) with suspicion of RMSF that present fever and 2 or more of the next symptoms: headache, myalgia, rash, nausea, pharyngeal hyperemia, vomiting, abdominal pain, neurological disorders.
- In addition to at least one of the next epidemiologycal fators: presence of vectors in areas of residence or endemic areas visited two weeks prior to the onset of symptoms, history of visiting or residing in areas with RMSF transmission in the last two weeks, existence of confirmed cases in the locality of origin, history of vector bite or contact with dogs in the two weeks.
Exclusion
- Other clinical suspicion rather than RMSF
- History of allergy to doxycycline, azithromycin, bean starch or bovine gelatin.
- Not signing the informed consent
- Pregnancy.
Key Trial Info
Start Date :
May 12 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
86 Patients enrolled
Trial Details
Trial ID
NCT05398055
Start Date
May 12 2022
End Date
December 31 2025
Last Update
May 31 2022
Active Locations (1)
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1
Hospital General de Mexicali
Mexicali, Estado de Baja California, Mexico, 21000