Status:
RECRUITING
Role of Glucose Metabolism in Migration of Cutaneous Dendritic Cells in Psoriasis
Lead Sponsor:
Centre Hospitalier Universitaire de Nice
Conditions:
Psoriasis
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Dendritic cells (DC) paly a key role in the induction and chronicity of psoriasis by capturing the antigenes and activating the T cell repsonse. This activation requires their migration from the cutan...
Eligibility Criteria
Inclusion
- Patients of both sexes
- hospitalized in the Dermatology department of the CHU of Nice for moderate to severe psoriasis (defined by a PASI \> or = 10)
- covered by a social security scheme after obtaining a free
- Clinical diagnosis of plaque psoriasis by a dermatologist with or without type 2 diabetes (defined by glycated hemoglobin \>7%)
- For the control group: without psoriasis or other inflammatory dermatosis aged in the presence or not of type 2 diabetes (glycated hemoglobin \>7%).
- free and informed consent
Exclusion
- Minor or incapable or unwilling to consent freely or in an informed manner Pregnant or nursing woman.
- Patient in a period of exclusion from other biomedical research
- Patient with generalized chronic inflammatory disease or other inflammatory dermatosis
- Patients on general corticosteroid, immunomodulator or immunosuppressant therapy in the month prior to local inclusion or treatment with corticosteroid therapy in the 15 days prior to inclusion, on anti- treatmentIL-23 or anti IL12/23 for less than 3 months or under anti-IL-17 or anti-TNF treatment for less than 1 month.
- Contraindication to cutaneous biospsis (known hemostasis disorder, taking anticoagulants, allergy to xylocaine, history of cheloid scars, congenital immune deficiency)
Key Trial Info
Start Date :
June 30 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT05399433
Start Date
June 30 2022
End Date
September 1 2026
Last Update
October 15 2024
Active Locations (1)
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1
CHU de Nice
Nice, Alpes-maritimes, France, 06001