Status:
ACTIVE_NOT_RECRUITING
Neoadjuvant PD-1 Inhibitor (Sintilimab), Anlotinib Combined With Chemotherapy in Resectable Stage IIA-IIIB NSCLC
Lead Sponsor:
Tang-Du Hospital
Conditions:
Sintilimab
Lung Cancer
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
Brief Summary
primary purpose：Observe the pathological complete response rate (PCR) of postoperative tumor tissue resection and evaluate the safety of the treatment process.
Detailed Description
primary purpose：Observe the pathological complete response rate (PCR) of postoperative tumor tissue resection and evaluate the safety of the treatment process. Description of the study design This is...
Eligibility Criteria
Inclusion
- pathological diagnosis of lung cancer, Age 18 years and 75 years old, physical strength status score 0-1;
- The investigator believes that the subject can comply with the study protocol;
- The investigator has confirmed to have at least one measurable lesion according to the RECIST1.1 criteria;
- Stage IIA, IIB, IIIA, IIIB NSCLC with histological or cytology proven operable treatment according to the International Association for Lung Cancer Research and the American Joint Committee on Cancer Staging version 8;
- Good hematopoietic function, defined as absolute neutrophil number 1.5X109 / L (no granulocyte colony stimulating factor support therapy), platelet count 100X109 / L, hemoglobin 90 g / L; (no transfusion or no erythropoietin dependence within 7 days);
- Good liver function, defined as 1.5 times the normal limit (ULN) of serum total bilirubin; ULN at 2.5 times transaminase (AST) and ALT); AST and ALT for recorded ULN;
- Good renal function, defined as serum creatinine 1.5 times ULN or calculated creatinine clearance of 60 ml/min (Cockcroft-Gault formula); routine urine protein less than 2 +, or 24h urine protein \<1g;
- Good coagulation function, defined as the international standardized ratio (INR) or prothrombin time (PT) 1.5 times ULN;
- The total amount of lung function (e. g., FVC, FEV1, TLC, FRC, and DLco) can tolerate the proposed lung resection procedure;
- For female subjects of childbearing age, the urine or serum pregnancy test should be negative within 3 days before receiving the first dose (cycle 1, day 1)
Exclusion
- 1 . Presof locally advanced unresectable or metastatic disease;
- . peripheral neuropathy;
- Active, known or suspected autoimmune diseases, type I diabetes, hypothyroidism that requires only hormone replacement therapy, skin diseases that do not require systemic treatment (such as vitiligo, psoriasis or alopecia), or diseases not expected to recur without external stimulus factors can be selected;
- 4\. Systemic treatment with corticosteroids (an equivalent dose of\> 10 mg prednisone per day) or other immunosuppressive drugs within 14 days before randomization.Inhalor topical steroids are permitted without active autoimmune disease.
- Active Hepatitis B / hepatitis C infection and known HIV;
- Patients who have previously received chemotherapy or any other anti-tumor therapy;
Key Trial Info
Start Date :
March 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 30 2026
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT05400070
Start Date
March 1 2021
End Date
December 30 2026
Last Update
October 18 2024
Active Locations (1)
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1
Tangdu Hospital, the Air Force Military University
Xi'an, China, 710038