Status:
COMPLETED
MRI Assessment of Impaired Glucose Metabolism in Alzheimer's Disease
Lead Sponsor:
University of Aarhus
Collaborating Sponsors:
Aarhus University Hospital
Conditions:
Alzheimer Disease
Eligibility:
All Genders
18-85 years
Brief Summary
Diseases of dementia are chronic, untreatable, and cause a massive burden of morbidity. In this proposal, we seek to tackle the problem of better, earlier, and more efficient diagnosis using deuterium...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- AD-patients:
- Aged 55-85 years.
- Male or female.
- AD diagnosis by the NIA-AA 2011 research criteria.8
- Able to give written informed consent.
- Mini-mental state examination (MMSE) equal to or above 18.9
- Brain FDG-PET performed at Aarhus University Hospital consistent with AD.
- Healthy participants:
- Aged 18-85 years.
- Male or female.
- Exclusion criteria:
- All participants:
- Diabetes or any other metabolic disease.
- Other significant brain disease:
- Strokes.
- Tumors.
- Chronic small vessel disease (clinically suspected, or Fazekas ≥ 2 if clinical MRI is available).
- Epilepsy.
- Other neurodegenerative or -inflammatory disease.
- Contraindications for MRI:
- Pacemaker, neurostimulator or cochlear implant.
- Metal foreign bodies such as fragments and irremovable piercings.
- Unsafe medical implants (safety of heart valves, hips and the like must be confirmed).
- Claustrophobia.
- Largest circumference including arms \> 160 cm.
- Pregnant - women must be post-menopausal or confirmed non-pregnant by an onsite test.
Exclusion
Key Trial Info
Start Date :
December 22 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 27 2023
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT05402566
Start Date
December 22 2022
End Date
October 27 2023
Last Update
December 1 2023
Active Locations (1)
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1
Aarhus University
Aarhus, Denmark, 8200