Status:
COMPLETED
Impact of TMAO Serum Levels on Hyperemic IMR in STEMI Patients
Lead Sponsor:
Lithuanian University of Health Sciences
Collaborating Sponsors:
Università degli Studi di Brescia
Kreiskrankenhaus Rotenburg
Conditions:
STEMI - ST Elevation Myocardial Infarction
Microvascular Coronary Artery Disease
Eligibility:
All Genders
40+ years
Brief Summary
Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of dietary choline, L-carnitine, and phosphatidylcholine-rich foods. On the basis of experimental studies and patients with preva...
Eligibility Criteria
Inclusion
- Patient diagnosed with STEMI
- Availability of non- left anterior descending artery (LAD) non culprit lesion, which is planned for a staged Percutaneous coronary intervention (PCI)
Exclusion
- patient undergoing cardiopulmonary resuscitation;
- patients with a history of old myocardial infarction or history of coronary artery bypass grafting (CABG) or Percutaneous coronary intervention PCI
- Patients with signs of chronic infection, prolong usage of corticosteroids or compromised immune system
- patients had thrombolysis before primary Percutaneous coronary intervention (pPCI)
- had contraindication of adenosine triphosphate (ATP);
- had a history of liver or renal function dysfunction
- Patients with dementia
- Patients being referred to CABG after primary PCI
- unable to provide informed consent;
- had pregnancy or life span \< 1 year.
- Presence of sever structural valvular heart disease
- Presence of significant left main disease
- Unability to measure the index of microcirculatory resistance due to (death or retraction from the study ...etc)
- Inability to perform successful PCI
Key Trial Info
Start Date :
January 12 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2022
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT05406297
Start Date
January 12 2021
End Date
August 1 2022
Last Update
August 16 2022
Active Locations (1)
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1
Ali Aldujeli
Kaunas, Lithuania, LT-50161