Status:
RECRUITING
Personalized Tidal Volume in ARDS (VT4HEMOD)
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Acute Respiratory Distress Syndrome
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Treatment of acute respiratory distress syndrome (ARDS) relies on invasive mechanical ventilation with supposedly protective settings (low tidal volume ventilation). Mortality of ARDS remains high in ...
Eligibility Criteria
Inclusion
- Age greater then 18 years old
- ARDS according to the BERLIN definition with PaO2/FiO2 ratio ≤ 150 mm Hg
- invasive mechanical ventilation in volume controlled mode with tidal volume set to 6 ml/kg predicted body weight
- use of sedation and neuromuscular-blocking agents
- arterial catheter allowing computation of pulse contour cardiac output calibrated with thermodilution
- central venous catheter implanted in the superior vena cava territory
- esophageal balloon
- Computed tomography planned by attending physician
Exclusion
- Previous inclusion in current study
- Acute cor pulmonale
- ECMO
- Arterial pH \< 7.21 despite respiratory rate set to a maximum of 35/min
- Pneumothorax or bronchopleural fistula
- Decision to withdraw or withhold life sustaining treatment with 24 hours from inclusion
- Contra-indication of transport to imaging facility
- Intracranial hypertension
- Tricuspid or pulmonary mechanical valve
- Tricuspid or pulmonary infective endocarditis
- Pace maker with intracardiac leads
- Right ventricle tumor
- Complete left bundle block
- Intrathoracic metallic device
- COPD
- Cardiac arrythmia
- Vesical pressure \> 15 mm Hg
- Lower limb amputation
- Inferior vena cava thrombosis
- Patient under an exclusion period relative to participation to another clinical trial
- Patient under a legal protective measure
- Patient not affiliated to social security
- lac of patient/representative consent
- Pregnancy
- Breast feeding
Key Trial Info
Start Date :
December 29 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT05406570
Start Date
December 29 2022
End Date
December 1 2026
Last Update
November 19 2024
Active Locations (1)
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1
Hospices Civils de Lyon - Hôpital de la Croix Rousse - Service de Médecine Intensive Réanimation
Lyon, France, 69004