Status:
COMPLETED
Study of Radiolabeled Revumenib in Adults With Acute Leukemia
Lead Sponsor:
Syndax Pharmaceuticals
Conditions:
Acute Leukemia
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
This is an open-label study to evaluate the absorption, metabolism, and excretion (AME) of carbon-14 (\[14C\])-revumenib in participants with acute leukemia.
Detailed Description
Participants will be enrolled in this study primarily to complete the 11-day AME portion of the study; participants who are receiving benefit from revumenib may remain on study until progressive disea...
Eligibility Criteria
Inclusion
- Key
- Males and females (of non-childbearing potential) aged ≥18 years
- Relapsed or refractory acute leukemia, including participants who are MRD-positive by multiparametric flow cytometry or next-generation sequencing, and including participants with isolated extramedullary disease.
- Previously received standard of care therapy
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 2
- Adequate liver and cardiac function
- Fertile males agree to use barrier contraception from the time of enrollment through 120 days after the last study drug dose
- Key
Exclusion
- Active diagnosis of acute promyelocytic leukemia
- White blood cell (WBC) count \>25,000/microliters at time of enrollment.
- Detectable human immunodeficiency virus viral load within the previous 6 months
- Hepatitis B or Hepatitis C
- Cardiac, gastrointestinal, or graft-versus-host disease (GVHD)
- History of or any concurrent condition, therapy, laboratory abnormality, or allergy to excipients that might confound the results of the study, interfere with the participant's ability to participate for the full duration of the study, or not be in the best interest of the participant to participate
- Must not be receiving any moderate or strong cytochrome P450 3A4 (CYP3A4) inhibitor/inducers
- Any commercially available or investigational antileukemic therapy other than revumenib except for short-term administration of corticosteroids and/or hydroxyurea for cytoreduction
- Participation in another therapeutic interventional clinical study in which an investigational agent was administered within 30 days before starting revumenib
- Any concurrent systemic treatment to prevent GVHD
Key Trial Info
Start Date :
August 5 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 18 2024
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT05406817
Start Date
August 5 2022
End Date
November 18 2024
Last Update
January 10 2025
Active Locations (1)
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1
MD Anderson Cancer Center
Houston, Texas, United States, 77030