Status:
NOT_YET_RECRUITING
Establishment and Clinical Application of Risk Classification Model Based on Molecular Typing of Medulloblastoma in Children
Lead Sponsor:
Beijing Tiantan Hospital
Collaborating Sponsors:
Beijing Neurosurgical Institute
Beijing Children's Hospital
Conditions:
Medulloblastoma, Childhood
Eligibility:
All Genders
6-18 years
Brief Summary
The purpose of this study:(1) Development of a new risk classification model for childhood medulloblastoma. (2) Evaluation and improvement of existing individualized treatment protocols.
Detailed Description
Medulloblastoma (medulloblastoma, MB) is the most common intracranial malignant tumor in children, accounting for 20% of all central nervous system tumors in children, seriously affecting the quality ...
Eligibility Criteria
Inclusion
- Age 0.5-18 years (except neonates).
- Pathologically confirmed medulloblastoma.
- Not having received any other relevant treatment before surgery.
- Completion of enhanced MRI of the head and spinal cord.
- Availability of tumor samples and determination of molecular typing.
- Postoperative KPS score ≥ 70.
- Voluntary enrollment in the group and the ability to receive long-term follow-up.
- The patient or the patient's family voluntarily signed the informed consent form.
Exclusion
- Patients who have recently received other drugs or radiation therapy.
- Patients suffering from acute or chronic infectious diseases
- Patients suffering from neurological or psychiatric diseases or mental disorders that cannot be easily controlled, or poor compliance.
- Patients who cannot receive enhanced MRI scans.
- Other conditions that the investigator believes make the patient unfit to participate in this trial.
Key Trial Info
Start Date :
January 30 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2030
Estimated Enrollment :
350 Patients enrolled
Trial Details
Trial ID
NCT05406947
Start Date
January 30 2023
End Date
December 31 2030
Last Update
February 8 2023
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