Status:
COMPLETED
Cranberry Ingestion and Cycling Related Immunity and Inflammation
Lead Sponsor:
Appalachian State University
Collaborating Sponsors:
Ocean Spray, Inc.
Conditions:
Inflammatory Response
Metabolic Disturbance
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
This is a randomized, crossover clinical trial with 25 male and female cyclists. Study participants will ingest polyphenol-rich cranberry juice or placebo juice for 4 weeks under double-blinded proced...
Detailed Description
RESEARCH DESIGN: Subjects will come to the lab for orientation/baseline testing, pre-and post-supplementation (4 weeks cranberry ingestion compared to water alone) blood, stool, and urine sample colle...
Eligibility Criteria
Inclusion
- Male or female cyclist, ages 18-55 years, and capable of cycling 2.25 h in the lab on trainers at 70% VO2max (close to race pace).
- Non-smoker
- Generally healthy and without chronic disease including cardiovascular disease (e.g., heart disease, stroke), cancer, type 1 and 2 diabetes, rheumatoid arthritis.
- Categorized as "low risk" using the American College of Sports Medicine screening questionnaire.
- Agree to train normally, maintain weight, and avoid the regular use of large-dose vitamin and mineral supplements, herbs, and medications that influence inflammation (especially NSAIDs) for the duration of the 10-week study.
- Agree to taper their exercise routine prior to each of the two lab cycling sessions.
- Agree to avoid ingestion of cranberry products during the study (other than provided).
Exclusion
- Inability to comply with study requirements.
- History of allergic reactions to cranberry ingestion.
- Females: body weight below 110 pounds; pregnant or breastfeeding.
- Any other concurrent condition which, in the opinion of the principle investigator (PI), would preclude participation in this study or interfere with compliance.
- Current diagnosis of cardiovascular disease, diabetes, or cancer (except for non-melanoma skin cancer).
Key Trial Info
Start Date :
June 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 15 2023
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT05407701
Start Date
June 1 2022
End Date
January 15 2023
Last Update
January 26 2023
Active Locations (1)
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1
Appalachian State University Human Performance Lab, North Carolina Research Campus
Kannapolis, North Carolina, United States, 28081