Status:
UNKNOWN
Assessment of FOXP3 Gene Polymorphisms and Serum Interleukin 10 in Patients With ITP
Lead Sponsor:
Sohag University
Conditions:
Thrombocytopenia
Eligibility:
All Genders
18+ years
Brief Summary
Immune thrombocytopenia (ITP) is an autoimmune condition characterized by increased platelet destruction and suppression of production resulting in isolated thrombocytopenia. The exact etiology of ITP...
Detailed Description
The suppressor function of Treg cells may be compromised if the FOXP3 gene is deficient. FOXP3 gene single nucleotide polymorphisms (SNPs), particularly regulatory polymorphisms in the promoter region...
Eligibility Criteria
Inclusion
- Patients with primary ITP and aged 18 and older will be included in the study.
Exclusion
- Patients under 18 and those with proven secondary ITP \[as cases initiated by or associated with infections due to human immunodeficiency virus (HIV-associated), hepatitis B virus, or hepatitis C virus-associated secondary ITP\] .
- Patients with accompanying autoimmune disorders such as systemic lupus erythematosus (SLE).
- Patients with malignancies will be excluded
Key Trial Info
Start Date :
June 10 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2023
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT05410249
Start Date
June 10 2022
End Date
September 30 2023
Last Update
April 12 2023
Active Locations (1)
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1
Faculty Of Medicine
Sohag, Egypt, 82524