Status:
RECRUITING
Hybrid Ablation of Atrial Fibrillation in Heart Failure
Lead Sponsor:
St. George's Hospital, London
Conditions:
Persistent Atrial Fibrillation
Atrial Fibrillation, Persistent
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
A randomised controlled trial to assess the efficacy of staged hybrid ablation when compared with standard catheter ablation in patients with non-paroxysmal atrial fibrillation (AF) and Heart Failure
Detailed Description
The objective of this randomized study is to evaluate the safety and efficacy of Convergent hybrid ablation when compared to standard catheter ablation in patients with non-paroxysmal AF and heart fai...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Persistent or Long-standing Persistent AF
- Dilated left atrium (at least moderately dilated)
- Suitable for either procedure
- LVEF \< 50%
Exclusion
- Not yet optimised from a medical or lifestyle perspective for AF or heart failure
- Unable to provide written consent
- Previous open-heart surgery
- Active infection, oesophageal ulcer stricture or oesophageal varices
- Prior catheter ablation of atrial fibrillation (prior ablation for atrial flutter / supraventricular tachycardia or ventricular arrhythmia acceptable)
- Contraindication to anticoagulation, or active thrombus in the left atrium despite therapeutic anticoagulation
- Severe valvular heart disease
- Unstable coronary artery disease
- Uncontrolled ventricular arrhythmia
- Heart attack or stroke within the last 90 days
- Pregnant, breastfeeding, or women of childbearing age who plan to get pregnant within six months
- Severe concomitant condition or presence of an implanted device that would preclude the patient from undergoing trial procedures
Key Trial Info
Start Date :
June 25 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2027
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT05411614
Start Date
June 25 2022
End Date
October 1 2027
Last Update
November 28 2025
Active Locations (7)
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1
Ashford & St Peters Hospital NHS Trust
Chertsey, United Kingdom
2
Epsom General Hospital
Epsom, United Kingdom
3
Cromwell Hospital
London, United Kingdom
4
Royal Surrey County Hospital
London, United Kingdom