Status:
COMPLETED
Oral Ketones and Exercise Among Patients With Long-chain Fatty Acid Oxidation Disorders
Lead Sponsor:
Oregon Health and Science University
Conditions:
Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency
Carnitine Palmitoyltransferase Deficiency 2
Eligibility:
All Genders
18+ years
Phase:
EARLY_PHASE1
Brief Summary
The purpose of the study is to determine if an oral ketone beverage is safe and well-tolerated during moderate intensity exercise in participants with long-chain fatty acid oxidation disorders and if ...
Detailed Description
Purpose: Subjects with long-chain fatty acid oxidation disorders (LC-FAOD) do not make ketones during fasting or with exercise. Ketones are an important alternative energy substrate during moderate ex...
Eligibility Criteria
Inclusion
- confirmed diagnosis of VLCAD, LCHAD/TFP or CPT2 deficiency
- speak English
- willing to complete 2 moderate intensity exercise treadmills
Exclusion
- subjects actively participating in another research study that prohibits their participation
- pregnant females
- subjects with diabetes or taking medications to treat diabetes
Key Trial Info
Start Date :
August 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 22 2024
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT05411835
Start Date
August 1 2022
End Date
January 22 2024
Last Update
April 2 2024
Active Locations (1)
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1
Oregon Health & Science University
Portland, Oregon, United States, 97239